... • Can letairis lower platelets? • How has Orenitram worked for you?  Can you relate?Have another topic you'd like to discuss or explore? Go to myPHteam today and start the conversation. You'll be surprised just how many others may share similar stories.Feel free to ask a question here. ...
    
   
  
    Treatments and PH
    
      ... • Can letairis lower platelets? • How has Orenitram worked for you?  Can you relate?Have another topic you'd like to discuss or explore? Go to myPHteam today and start the conversation. You'll be surprised just how many others may share similar stories.Feel free to ask a question here. ...
     
    
   
 
      
  
  
  
    ... These medications include endothelin receptor antagonists like Tracleer (bosentan), Letairis (ambrisentan), and Opsumit (macitentan), as well as phosphodiesterase 5 inhibitors like Revatio (sildenafil).One myPHteam member was perplexed about a “chronic stuffy nose, cough, and shortness of breath,” after four months on a PH medication. ...
    
   
  
    Managing Allergies and Pulmonary Hypertension
    
      ... These medications include endothelin receptor antagonists like Tracleer (bosentan), Letairis (ambrisentan), and Opsumit (macitentan), as well as phosphodiesterase 5 inhibitors like Revatio (sildenafil).One myPHteam member was perplexed about a “chronic stuffy nose, cough, and shortness of breath,” after four months on a PH medication. ...
     
    
   
 
      
  
  
  
    ... Drugs that fall into this class include: Ambrisentan (Letairis) Macitentan (Opsumit) Bosentan (Tracleer)  Side Effects of Endothelin Receptor AntagonistsAs with many other PH medications, ERAs can result in low blood pressure and can cause side effects such as nausea and dizziness. ...
    
   
  
    Pulmonary Hypertension Treatments and Their Side Effects
    
      ... Drugs that fall into this class include: Ambrisentan (Letairis) Macitentan (Opsumit) Bosentan (Tracleer)  Side Effects of Endothelin Receptor AntagonistsAs with many other PH medications, ERAs can result in low blood pressure and can cause side effects such as nausea and dizziness. ...
     
    
   
 
      
  
  
  
    ... Endothelin receptor antagonists (ERAs) have been shown to reduce blood pressure in the lungs by blocking endothelin-1 from binding to cells in the body.The FDA has approved three ERAs for the treatment of pulmonary arterial hypertension: Ambrisentan (sold as Letairis) — Blocks endothelin A receptors Macitentan (Opsumit) — Blocks both endothelin A and ...
    
   
  
    PAH Pathways Explained: 4 Types and How Treatments Target Them
    
      ... Endothelin receptor antagonists (ERAs) have been shown to reduce blood pressure in the lungs by blocking endothelin-1 from binding to cells in the body.The FDA has approved three ERAs for the treatment of pulmonary arterial hypertension: Ambrisentan (sold as Letairis) — Blocks endothelin A receptors Macitentan (Opsumit) — Blocks both endothelin A and ...
     
    
   
 
      
  
  
  
    ... These include: Ambrisentan (Letairis) — Blocks endothelin A receptors Bosentan (Tracleer) — Blocks both endothelin A and endothelin B receptors Macitentan (Opsumit) — Blocks both endothelin A and endothelin B receptors Studies show these medications can help lower mPAP and improve PAH symptoms and disease outcomes. ...
    
   
  
    Combination Therapy for PAH: 6 Facts About Endothelin and PAH
    
      ... These include: Ambrisentan (Letairis) — Blocks endothelin A receptors Bosentan (Tracleer) — Blocks both endothelin A and endothelin B receptors Macitentan (Opsumit) — Blocks both endothelin A and endothelin B receptors Studies show these medications can help lower mPAP and improve PAH symptoms and disease outcomes. ...
     
    
   
 
      
  
  
  
    ... Its Effect on Health-Related Quality of Life Over Time in Patients With Pulmonary Hypertension: A Multisite Longitudinal Cohort Study — BMJ Open Respiratory Research Learn About Pulmonary Arterial Hypertension — American Lung Association Pulmonary Hypertension (PH) — Cleveland Clinic Pulmonary Arterial Hypertension — Cleveland Clinic Ambrisentan (Letairis ...
    
   
  
    How To Treat Shortness of Breath With PAH
    
      ... Its Effect on Health-Related Quality of Life Over Time in Patients With Pulmonary Hypertension: A Multisite Longitudinal Cohort Study — BMJ Open Respiratory Research Learn About Pulmonary Arterial Hypertension — American Lung Association Pulmonary Hypertension (PH) — Cleveland Clinic Pulmonary Arterial Hypertension — Cleveland Clinic Ambrisentan (Letairis ...
     
    
   
 
      
  
  
  
    ... Drugs in this category such as bosentan (Tracleer) and ambrisentan (Letairis) can keep the blood vessels from becoming too narrow.Other medications for PAH may work in different ways. ...
    
   
  
 
      
  
  
  
    ... Rare but serious side effects include an increased risk of bleeding.Endothelin Receptor AntagonistsAmbrisentan (Letairis), macitentan (Opsumit), and bosentan (Tracleer) are endothelin receptor antagonists (ERAs). ...
    
   
  
 
      
  
  
  
    ... Letairis (ambrisentan) and Tracleer (bosentan) may allow people with PAH to exert themselves physically without shortness of breath and walk farther on a six-minute exercise test.1,17 Opsumit (macitentan) may slow disease progression and potentially reverse some heart and lung damage caused by PAH.1 Phosphodiesterase-5 (PDE-5) inhibitors — PDE-5 inhibitors ...
    
   
  
    Pulmonary Arterial Hypertension (PAH) Diagnosis and Treatments
    
      ... Letairis (ambrisentan) and Tracleer (bosentan) may allow people with PAH to exert themselves physically without shortness of breath and walk farther on a six-minute exercise test.1,17 Opsumit (macitentan) may slow disease progression and potentially reverse some heart and lung damage caused by PAH.1 Phosphodiesterase-5 (PDE-5) inhibitors — PDE-5 inhibitors ...