myPHteam

What a journey you've been on since your 2022 diagnosis — trying multiple treatments takes real persistence, and it makes complete sense to want to know what to expect before starting Uptravi (selexipag).

Uptravi belongs to a class called prostacyclin receptor agonists. It works by relaxing and widening the blood vessels Show Full Answer

What a journey you've been on since your 2022 diagnosis — trying multiple treatments takes real persistence, and it makes complete sense to want to know what to expect before starting Uptravi (selexipag).

Uptravi belongs to a class called prostacyclin receptor agonists. It works by relaxing and widening the blood vessels in the lungs, which helps reduce the workload on the heart. Some side effects are fairly common, especially when first starting or increasing the dose. These can include:

- Headaches
- Jaw pain
- Nausea or diarrhea
- Flushing (redness/warmth in the face)
- Muscle or limb pain
- Low blood pressure

Many people find these side effects are most noticeable during dose increases and can ease over time. Starting low and going slow with dosing is typically how doctors manage this. Other myPHteam members have shared their experiences with Uptravi (Orenitram, a related prostacyclin). One myPHteam member noted asking others directly: *"How has Orenitram worked for you?"* — showing this is a very common and relatable question in the community.

It's worth keeping a symptom journal once you start, so you can track changes and discuss them clearly with your doctor. Wishing you the very best as you take this next step! 💙

 AI-generated responses are not a substitute for medical advice. These services are not intended to diagnose, treat, or cure any condition or disease. Always ask your doctor about specific health concerns.

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