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I have IPAH since 2018 and am taking ambrisentan, tadalafil and increased my uptravi since the development of the shunt. Wondering if their shunt closed down after quitting the winrevair and how long it took? They also put me on LASIK as I'm retaining water in my abdomen.

March 18
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A myPHteam Member

As a 30 year Nurse, the BEST ADVISE is to make the an appt with the Doctor (he has your medical records) that to put you on those medications, you need the TRUTH and the FACTS about these medications. You have remember, that all medications affect everyone differently, out body chemistry is different, it affects how the medications work. I can look up these meds and your condition, But, I do not have your medical history, I do not have experience with these medications. I would be giving you bad advise. Anyone who gives you advise, although they men well, they don't all the facts, like me. Please make an appt with the specific doctor to talk and in the mean time, google everything, make a list of questions, so you will have a better understanding and have questions for him. Mak an Appt with him, ASAP.

March 18
A myPHteam Member

Thank you, I do have an appointment on April 2. I've just been wondering if anyone else out there is experiencing the same

March 19
A myPHteam Member

First thing in the am, after you go to the bathroom, weigh yourself (in your birthday suit), keep a record of the weight. First thing in am, is the most accurate weight. This will tell you if you are retaining fluid and the lasix is not working. (if you start reaing fluid Now, woman"s weight goes up and down, 1-3 lbs a day. If you start gaining weight and fluid will build up in your abdomen and not losing it, could end up having your abdomen drained (you do not want this). How will you know? Every morning, after you go to the bathroom, in your birthday suit, weigh your self, same time, same place, same clothes record your weight, if you start seeing your weight going up and up and up, you need to go in and see your doctor. This is extremly important you do this as I have explained. This will help in preventing other problems. Ask the Doctor who gave you the meds, is this fluid retention has something to do with Shunt. Make an Appt with Your DOCTOR.

March 18
myPHteam

Has anyone had to stop Winrevair due to right heart shunt development, and did the shunt close after stopping?

This is a very specific and concerning situation. Right heart shunts can develop when there's abnormal blood flow between the heart chambers, which can increase pressure on the right side of the heart and Show Full Answer

Has anyone had to stop Winrevair due to right heart shunt development, and did the shunt close after stopping?

This is a very specific and concerning situation. Right heart shunts can develop when there's abnormal blood flow between the heart chambers, which can increase pressure on the right side of the heart and pulmonary arteries.

Unfortunately, the available information doesn't include specific experiences from members who developed shunts while on Winrevair or how long it took for shunts to close after stopping the medication. This is likely because Winrevair is a relatively new treatment, approved in 2024, so long-term data on this particular complication is still emerging.

What you should know:

During right heart catheterization, doctors can assess for left-to-right shunts, which may be caused by holes in the heart allowing blood to flow backward. This type of assessment helps guide treatment decisions.

Your care team's response—stopping Winrevair, adjusting your other PAH medications (increasing Uptravi while continuing ambrisentan and tadalafil), and adding diuretics (Lasix) for fluid retention—shows they're actively managing the situation.

Moving forward:

Since this is an uncommon complication, your pulmonary hypertension center will likely monitor you closely with follow-up testing to see if the shunt resolves. Each person's response can vary significantly.

You might consider asking your care team about the expected timeline for reassessment and what signs of improvement to watch for.

March 18

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