PHOSPHODIESTERASE-5 (PDE-5) INHIBITOR
Sildenafil is a prescription drug approved by the Food and Drug Administration (FDA) to improve exercise and delay disease progression in cases of pulmonary arterial hypertension. Sildenafil is sold under the brand names Revatio and Viagra.
Sildenafil is a phosphodiesterase-5 (PDE-5) inhibitor. Sildenafil inhibits the action of an enzyme called phosphodiesterase-5 (PDE-5), which works to control blood flow. In cases of pulmonary hypertension, Sildenafil is believed to work by dilating the pulmonary arteries.
How do I take it?
Prescribing information states that Sildenafil is taken three times a day orally or by intravenous injection.
Sildenafil comes in tablet, oral suspension, and single-use vial forms.
The FDA-approved label for Sildenafil lists common side effects including headache, insomnia, flushed skin, cold symptoms, stomach upset, muscle aches, tingling in the extremities, sensitivity to light, nosebleeds, and dyspnea (difficulty breathing).
Rare but serious side effects listed for Sildenafil include hypotension (low blood pressure), painful or prolonged erection, and vision or hearing problems.
For more details about this treatment, visit:
Sildenafil – MedlinePlus
Revatio – Pfizer
Phosphodiesterase 5 inhibitors– Pulmonary Hypertension Association UK