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A myPHteam Member asked a question 💭
Scottsdale, AZ

@A myPHteam Member posted about this exciting new medication who will be in a clinical trial for: Elafin. It is hoped that it will be curative for PAH.

October 7
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myPHteam

How exciting that a myPHteam member will be participating in a clinical trial for Elafin! That's a meaningful contribution to PAH research. Here's what is currently known about it:

Elafin works by blocking an enzyme called elastase, which breaks down a protein that keeps the blood vessels in your lungs strong and flexible.

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How exciting that a myPHteam member will be participating in a clinical trial for Elafin! That's a meaningful contribution to PAH research. Here's what is currently known about it:

Elafin works by blocking an enzyme called elastase, which breaks down a protein that keeps the blood vessels in your lungs strong and flexible.

People with PAH tend to have higher levels of this enzyme, which can cause blood vessels to become stiff and thickened. By blocking elastase, Elafin may help protect those vessels and keep them functioning better. Here's where things stand with the research:

- In an early clinical study, Elafin was shown to be safe and well tolerated
- No serious side effects were reported in that early study
- A Phase 2 clinical trial in people with PAH is expected to begin in 2026

It's worth noting that while the early results are promising, it's still in early stages. Whether it could be curative is something the upcoming trials will help answer. Wishing the myPHteam member the very best in the trial — participants like them are how breakthroughs happen! 💙

October 7
A myPHteam Member

Presumably at this point it is a cure for PAH, so you would no longer take any medications for PAH once the course is complete because you would no longer have PAH. I asked the doctor the same question. I couldn't wrap my head around no PAH drugs after.

I only heard of it this past Monday at my doctor appt when he told me about the clinical trial coming. Maybe ask Chatgpt and research. The study is out of Stanford and will occur sometime in late November or early December.

October 7
A myPHteam Member

Based upon the tiny bit I know thus far about it, which is scant to say the least, it might even be a one only medication that can be taken without the other "pathway" meds.

This is still being aimed ONLY for PAH, Group 1, so I don't know how much else I'm gonna hear about it since I am in Group 2.

October 7
A myPHteam Member

I went to a PH Wellness Expo in South San Francisco with my daughter (my angel, really) last Saturday and PAH specialists from Stanford University Hospital and University of California San Francisco spoke and this miracle cure was mentioned. I'm praying for all of my PAH friends to get access to this drug if it gets approved and truly works! By the way, the Expo that we attended was fabulous! I learned more on Saturday about our conditions than I've ever learned and I connected with patients, specialists and several companies that I already obtain meds from and by the end of the day, I was wiped out (but in a good way!) If you want me to email you photos of the program and all of the info they gave out, feel free to email me at (Email address can only be seen by the question and answer creators) and I'll get them to you!!!

October 12 (edited)
A myPHteam Member

Kim: That sounds so amazing and so promising! Thank you!

October 12

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