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Real members of myPHteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Are GLP 1 drugs safe to use with CTEPH and PAH?

A myPHteam Member asked a question 💭
Eugene, OR
May 25
 · 
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A myPHteam Member

I am PH Group 2 Left Heart Disease and have been on Wegovy for about 7 months now, primarily for my heart failure but secondarily for weight loss.

I had to go off the Wegovy for a couple of weeks before 3 different procedures: an Ablation, getting a Watchman device implanted, and having a Transesophogeal Endoscopy. I'm not really clear on why I had to have those interruptions to my taking the GLP-1 med. I was told it had something to do with how much sugar the medication removes from your system and getting through the anesthesia...but I don't know if there isn't more to it than that.

Other than those procedure related interruptions, I have had no issues other than some constipation and now that I am on the highest dosage, a little brain fog and balance issues which seem to be going away.

I've lost 24 pounds so far.

May 25 (edited)
myPHteam

Great question, and one worth exploring carefully. GLP-1 drugs (like semaglutide/Ozempic) are primarily used for managing blood sugar and weight loss. There's no conclusive evidence that they cause or worsen pulmonary hypertension, but research is still ongoing — especially for people with CTEPH and PAH. Here are some key Show Full Answer

Great question, and one worth exploring carefully. GLP-1 drugs (like semaglutide/Ozempic) are primarily used for managing blood sugar and weight loss. There's no conclusive evidence that they cause or worsen pulmonary hypertension, but research is still ongoing — especially for people with CTEPH and PAH. Here are some key things to keep in mind:

- Medication interactions: PAH and CTEPH treatments often include vasodilators, blood thinners, and diuretics. GLP-1 drugs could potentially interact with these, so a conversation with your doctor is essential before starting them.
- Side effects to watch for: Common side effects include nausea, vomiting, and diarrhea. More serious but rare effects include breathing problems and changes in heart function — both worth monitoring closely given your condition.
- Weight management benefit: Weight loss from GLP-1 drugs may help ease pressure on the heart and lungs, which could be a positive factor for some people with PH. The bottom line: GLP-1 drugs aren't automatically off-limits, but they require careful consideration alongside your existing treatment plan. A specialist familiar with your PH management is the best person to help weigh the benefits and risks for your specific situation.

May 25

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