That's a really important question, and the short answer is: yes, it's possible for a medication like Opsumit to become less effective over time. But sudden worsening of breathlessness and fatigue after a period of stability is always worth taking seriously and discussing with your doctor promptly.
There are a few reasons Show Full Answer
That's a really important question, and the short answer is: yes, it's possible for a medication like Opsumit to become less effective over time. But sudden worsening of breathlessness and fatigue after a period of stability is always worth taking seriously and discussing with your doctor promptly.
There are a few reasons why symptoms might suddenly worsen:
- Disease progression – Pulmonary hypertension can advance even while on treatment, meaning the medication may need to be adjusted or a second medication added
- Reduced medication response – Some people find their current treatment becomes less effective over time
- New or changing factors – Other things happening in the body can affect how well treatment is working A myPHteam member shared a similar experience, noting that their specialist felt their PAH was advancing and they were awaiting further testing.
It's really important to contact your doctor soon — especially since these symptoms have been going on for 6 weeks. They may consider:
- Adjusting your current medication dose
- Adding a second medication (combination therapy is common)
- Running tests like a right heart catheterization or lung function tests to assess what's changed
Don't wait on this one — worsening breathlessness and fatigue are key signs your care team needs to know about right away.
May 15
Thank you Heather; I have read about Winrevair . I meet with my MD on Tuesday and I am certain we will be discussing next steps.
May 22
Remember, none of the PAH meds are considered to be curatives; they help extend life and help improve the QOL But the illness continues to be progressive, even if at a slower pace than it would without the meds. Some people believe that over time Winrevair will be seen as curative, but it is just too soon to know that.
May 22
A cardiac cath should be ordered if you notice such a change if you haven't had one in a year. GT, RN
May 22
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