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Real members of myPHteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A myPHteam Member asked a question 💭
April 21
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What are the pros and cons of Opsumit (macitentan)?

Opsumit is an endothelin receptor antagonist used to treat pulmonary arterial hypertension. Here's what to know:

Pros
- Helps slow disease progression in PAH
- May improve heart and lung function
- Can be used in combination therapy with other PAH medications
- Show Full Answer

What are the pros and cons of Opsumit (macitentan)?

Opsumit is an endothelin receptor antagonist used to treat pulmonary arterial hypertension. Here's what to know:

Pros:
- Helps slow disease progression in PAH
- May improve heart and lung function
- Can be used in combination therapy with other PAH medications
- Financial assistance is available through Janssen CarePath for eligible patients with commercial insurance (currently $5 per prescription fill)
- Some specialty pharmacies may offer zero deductible options

Cons:
- Can be very expensive without assistance
- Common side effects include headache, nausea, flushed skin, and diarrhea
- Rare but serious side effects include increased risk of bleeding
- Financial assistance programs typically don't apply to Medicare or Medicaid patients

A myPHteam member shared: "I talked to my specialty pharmacy. I get Opsumit for zero deductible. I was so worried. I know it is very expensive."

If cost is a concern, talk to your doctor about patient assistance programs or specialty pharmacies that may help reduce out-of-pocket expenses.

April 21

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