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Real members of myPHteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
August 30, 2025
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A myPHteam Member

After my cardiologist diagnosed me with PAH in February, i was first put on ambersantin (forgive the spelling) and slidenofil (sp?) But i had poor results. Now I take opsenvi and its working amazingly well. To help with the selling, my doctor changed my diuretic from Lasix to 2 tablets of 60mg torsemide. It really makes a difference. I go back to the cardiologist next week, and they are probably going to add something else to help even more. But I rarely need my inhaler, however I still have some shortness of breath. And I can't do yard work like before. I recommend asking g about torsemide, its control release. I have to have that due to left side heart failure as well

August 30, 2025
A myPHteam Member

Teresa I hope you get some responses for opsenvi.
AI didn't do a very
good job.
I take Opsumit but don't have edema side effects.

August 30, 2025 (edited)
myPHteam

Endothelin receptor antagonists (ERAs) like Opsumit can indeed cause fluid buildup and edema as a side effect. Common signs of edema include swelling in arms and legs, skin that appears stretched or shiny, and a heavy feeling in the legs. If you're experiencing edema, talk to your doctor as they may prescribe a diuretic Show Full Answer

Endothelin receptor antagonists (ERAs) like Opsumit can indeed cause fluid buildup and edema as a side effect. Common signs of edema include swelling in arms and legs, skin that appears stretched or shiny, and a heavy feeling in the legs. If you're experiencing edema, talk to your doctor as they may prescribe a diuretic (water pill) to help manage the swelling. Many myPHteam members report good results with diuretics for managing fluid retention. However, it's important to monitor your weight daily and watch for signs of dehydration if taking diuretics.

Contact your doctor immediately if you:
• Gain 2-3 pounds in one day
• Gain 5+ pounds in a week
• Experience increased leg/ankle swelling
• Feel short of breath while resting
• Have difficulty lying flat or sleeping

August 30, 2025

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Austin, Texas, TX