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I had tried PDE5 inhibitors and developed massive edema from generalized vasodilation effects & weight gain of 22 lbs in 2-3 months (that I just understood today after
reading in myphteam article !)
I will never use PDE5 inhibitors for PH again.

July 27, 2025
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Nitric Oxide for Pulmonary Hypertension: Uses, Drug Interactions, and Blood Thinners Read Article...
myPHteam

Inhaled nitric oxide is administered as a gas that you breathe in through your mouth or nasal cannula, sometimes in combination with a ventilator. While using this treatment, doctors will closely monitor your
- Blood oxygen levels
- Pulmonary arterial pressure
- Overall blood pressure

One advantage of inhaled nitric oxide Show Full Answer

Inhaled nitric oxide is administered as a gas that you breathe in through your mouth or nasal cannula, sometimes in combination with a ventilator. While using this treatment, doctors will closely monitor your:
- Blood oxygen levels
- Pulmonary arterial pressure
- Overall blood pressure

One advantage of inhaled nitric oxide is that it specifically targets the lungs rather than affecting blood vessels throughout the entire body, which can help minimize systemic side effects. It's important to note that while inhaled nitric oxide can be used for PAH, it is not specifically FDA approved for adults with this condition. The effectiveness varies among individuals, who are typically categorized as either "responders" or "nonresponders" based on how well the treatment reduces their:
- Pulmonary vascular resistance
- Mean pulmonary artery pressure

Given your experience with PDE5 inhibitors, discussing inhaled nitric oxide as an alternative treatment option with your healthcare provider would be worthwhile, as it may offer more targeted relief with fewer systemic side effects.

July 27, 2025

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