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List of Treatments for Pulmonary Hypertension

See what members are saying about pulmonary hypertension treatments, the side effects to expect, and the drug basics.

All treatment information is medically reviewed · February 20, 2026

Adcirca (Tadalafil)

Overview
Adcirca is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to improve exercise in cases of pulmonary arterial hypertension. Adcirca may be referred to by its drug name, tadalafil…

Adempas (Riociguat)

Overview
Adempas is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to improve exercise and function in adult cases of chronic thromboembolic pulmonary hypertension (CTEPH) and pulmonary…

Aldactone (Spironolactone)

Overview
Aldactone is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat hypertension, heart failure, edema, and other conditions. In cases of pulmonary hypertension, Aldactone may be…

Alyq (Tadalafil)

Overview
Alyq is approved by the U.S. Food and Drug Administration (FDA) for the treatment of pulmonary arterial hypertension (PAH) to improve exercise ability. People eligible for this treatment typically have New York…

Atrial septostomy

Overview
Some people with advanced pulmonary arterial hypertension (PAH) and severe right heart failure may be candidates for atrial septostomy surgery. Atrial septostomy can relieve pressure in the right side of the…

Bumex (Bumetanide)

Overview
Bumex is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat edema associated with congestive heart failure and other conditions. In cases of pulmonary hypertension, Bumex may be…

Cardizem (Diltiazem)

Overview
Cardizem is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat hypertension, chronic stable angina, and angina due to coronary artery spasm. Cardizem is sometimes prescribed to…

Coumadin (Warfarin)

Overview
Coumadin is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat and prevent thromboembolic events. Coumadin may also be prescribed in cases of pulmonary hypertension, especially…

Digoxin

Overview
Digoxin is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat adults with mild to moderate heart failure and atrial fibrillation. It is also approved to treat children with…

Flolan (Epoprostenol)

Overview
Flolan is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to improve exercise capacity in cases of pulmonary arterial hypertension (PAH). Flolan may be referred to by its drug name…

Heart-lung transplant

Overview
Heart-lung transplant may be an option for some people with end-stage heart and lung disease due to pulmonary hypertension (PH). However, heart-lung transplant also poses significant risk for serious…

Lanoxin (Digoxin)

Overview
Lanoxin is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat mild to moderate heart failure and atrial fibrillation in adults. Lanoxin may also be prescribed in cases of…

Letairis (Ambrisentan)

Overview
Letairis is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to improve exercise capacity and limit disease progression in cases of pulmonary arterial hypertension (PAH). Letairis is…

Liqrev (Sildenafil)

Overview
Liqrev is approved by the U.S. Food and Drug Administration (FDA) for the treatment of pulmonary arterial hypertension (PAH). Liqrev is prescribed to improve exercise ability and delay clinical worsening in…

Lung transplant

Overview
Lung transplant can prolong survival and improve lung function and quality of life in some people with pulmonary hypertension (PH). However, lung transplant also poses significant risk for serious complications…

Metolazone

Overview
Metolazone is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to treat hypertension and edema associated with congestive heart failure. In cases of pulmonary hypertension, Metolazone…

Mitral valve surgery

Overview
In some people with pulmonary hypertension (PH), the disease is caused by damage or a defect of the mitral valve of the heart. Mitral valve surgery can potentially be an effective treatment for PH in certain…

Opsumit (Macitentan)

Overview
Opsumit is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to delay disease progression in cases of pulmonary arterial hypertension (PAH). Opsumit may be referred to by its drug name…

Opsynvi (Macitentan and Tadalafil)

Overview
Opsynvi, approved by the U.S. Food and Drug Administration (FDA), is indicated for the chronic treatment of adults with pulmonary arterial hypertension (PAH, WHO group 1) at WHO functional class 2 and 3…

Orenitram (Treprostinil)

Overview
Orenitram is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to improve exercise capacity in cases of pulmonary arterial hypertension (PAH). Orenitram may be referred to by its drug…

Oxygen therapy

Overview
People with pulmonary hypertension caused by conditions such as chronic obstructive pulmonary disease (COPD), interstitial lung disease, and sleep apnea may develop hypoxia, or low levels of oxygen in the blood…

Procardia XL (Nifedipine)

The Procardia brand name has been discontinued in the U.S. for reasons unrelated to safety or effectiveness. Other brand names or generic alternatives may be available. If you’re currently taking this medication, talk to…

Pulmonary thromboendarterectomy (PTE)

Overview
Pulmonary thromboendarterectomy (PTE) surgery is a potential cure for some people with chronic thromboembolic pulmonary hypertension (CTEPH). CTEPH is a type of pulmonary hypertension wherein blood clots in…

Remodulin (Treprostinil)

Overview
Remodulin is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to improve exercise capacity in cases of pulmonary arterial hypertension (PAH). Remodulin is sometimes prescribed when…

Revatio (Sildenafil)

Overview
Revatio is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to improve exercise and delay disease progression in cases of pulmonary arterial hypertension. Revatio may be referred to by…

Tadliq (Tadalafil)

Overview
Tadliq is approved by the U.S. Food and Drug Administration (FDA) for the treatment of pulmonary arterial hypertension (PAH) Group 1. It is prescribed to improve exercise ability in individuals with PAH. Tadliq…

Tracleer (Bosentan)

Overview
Tracleer is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to improve exercise capacity and limit disease progression in adults with pulmonary arterial hypertension (PAH). Tracleer…

Tyvaso (Treprostinil)

Overview
Tyvaso is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to improve exercise capacity in cases of pulmonary arterial hypertension (PAH) and pulmonary hypertension associated with…

Uptravi (Selexipag)

Overview
Uptravi is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to delay disease progression and reduce the risk of hospitalization in cases of pulmonary arterial hypertension (PAH)…

Veletri (Epoprostenol)

Overview
Veletri is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to improve exercise capacity in cases of pulmonary arterial hypertension (PAH). Veletri may be referred to by its drug name…

Ventavis (Iloprost)

Overview
Ventavis is a prescription drug approved by the U.S. Food and Drug Administration (FDA) to improve symptoms and exercise capacity and to avoid deterioration in cases of pulmonary arterial hypertension (PAH)…

Winrevair (Sotatercept-Csrk)

Overview
Winrevair is approved by the U.S. Food and Drug Administration (FDA) for the treatment of adults with pulmonary arterial hypertension (PAH), also known as World Health Organization (WHO) Group 1 pulmonary…

Yutrepia (Treprostinil)

Overview
Yutrepia is approved by the U.S. Food and Drug Administration (FDA) for the treatment of pulmonary arterial hypertension and pulmonary hypertension associated with interstitial lung disease. It is prescribed to…

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