There are several exciting areas of research for new PAH treatments right now! Researchers are exploring therapies that go beyond managing symptoms and actually target the root causes of PAH.
Here's a summary of what's being studied:
- Tyrosine Kinase Inhibitors (TKIs): Drugs like imatinib and seralutinib are being tested Show Full Answer
There are several exciting areas of research for new PAH treatments right now! Researchers are exploring therapies that go beyond managing symptoms and actually target the root causes of PAH.
Here's a summary of what's being studied:
- Tyrosine Kinase Inhibitors (TKIs): Drugs like imatinib and seralutinib are being tested to help control abnormal cell growth in lung blood vessels. Early results are mixed but show some promise.
- Bone Morphogenetic Protein (BMP) Modulators: These aim to improve the balance of blood vessel cell growth, and when added to existing therapy, have shown improvements in exercise capacity.
- Bromodomain Inhibitors: Being studied to help prevent heart and lung damage in PAH. A drug called apabetalone showed early improvements in pulmonary resistance.
- Monoclonal Antibody (NOTCH3 blocker): A newer experimental antibody targets a protein called NOTCH3, which causes blood vessel walls to thicken. In animal studies, symptoms of PAH disappeared with no side effects — though human trials are still needed.
- Hormone-Targeted Therapy: Since females are at higher risk for PAH, researchers are studying whether antiestrogen treatments could help. It's always worth asking a PAH specialist about clinical trials or newer treatment options, especially if your current plan isn't giving you the results you'd hope for. The Pulmonary Hypertension Association's website also has a directory of accredited PH Care Centers across the U.S. that may be a helpful resource.
August 28
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