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Real members of myPHteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

RHC went fine; I will not start Sotatercept

A myPHteam Member asked a question 💭
Sterling, CO

I had my RHC and Echo on Thursday. It went fine, but the doc determined that Sotatercept will not help me with my PAH issue. It was discovered that my major issue is rapid dilation of my Pulmonary Artery, especially when I exercise. Doc said blood and O2 go through it like water from a garden hose, draining me of all my O2 reserves too quickly, which explains why I get so short of breath when engaging in cardio exercise. He attributed that to my PAH diagnosis, as well as my enlarged right heart… read more

November 9, 2025 (edited)
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A myPHteam Member

Hi Steven, I am sorry Winrevair will not work for you, but I am sure your Dr knows best. Hopefully they will find the right treatment for you soon. Have a good Sunday. God bless 🙌

November 9, 2025
A myPHteam Member

Well, I'm glad the procedure went well but I'm sorry that you don't get the "easy" answer of Winrevair. Keep us posted as to what alternatives your team comes up with.

November 9, 2025
myPHteam

What treatment options are available after an RHC shows sotatercept isn't suitable for PAH?

It's great that your RHC went smoothly and that you're getting clearer answers about what's happening with your heart and lungs. Understanding the underlying cause—especially the connection between the hole in your heart, the Show Full Answer

What treatment options are available after an RHC shows sotatercept isn't suitable for PAH?

It's great that your RHC went smoothly and that you're getting clearer answers about what's happening with your heart and lungs. Understanding the underlying cause—especially the connection between the hole in your heart, the enlarged right chamber, and how blood flows through your pulmonary artery—can really help guide treatment decisions.

Since your doctor determined sotatercept won't help your specific situation, you'll want to discuss other treatment pathways at your December follow-up. Your current combination of Opsumit and Adempas is already targeting multiple PAH pathways, which is important for managing the condition.

Your healthcare team might consider:

- Adjusting doses of your current medications
- Adding prostacyclin drugs, which help open and relax blood vessels
- Evaluating whether your unique anatomy (the heart defect causing the left-to-right shunt) needs additional intervention
- Monitoring your cardiac output and pulmonary vascular resistance through regular follow-ups

The enlarged right heart chamber and rapid oxygen depletion during exercise are both areas your cardiologist will likely focus on. Some people with structural heart issues like yours may need specialized approaches beyond standard PAH medications.

Keep track of your symptoms, especially breathlessness during activity, so you can give your doctor detailed information at your next appointment. This will help determine the best path forward for your specific situation.

November 9, 2025
A myPHteam Member

I was diagnosed with a hole in my heart when I was 42 years old. I was told it was congenital heart defect.... So my whole life i was being treated for "severe asthma"..... I don't have asthma. I played softball and soccer from 6 years old until I was like 16 years old. The hole was repaired, after that I was told I have complete right sided heart failure and Pulmonary Arterial Hypertension and congestive heart failure then things started adding up to me, when it came to my health history. 🤔. I was diagnosed 16 years ago.
I'm on oxygen
AMBRISENTAN
Sildenafil
Lassics

November 12, 2025

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