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Real members of myPHteam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

I am relatively new to Remodulin/Treprostinil via IV (catheter). Wondering if anyone has been using and some of the side effects you’ve had.

A myPHteam Member asked a question 💭
Stamford, CT

I’m still titrating up and find I have several days, after I increase doses, that I’m exhausted , but don’t see that anywhere as a side effect. Typically it evens out after a week or so, but just wondering if others experience the same.

August 24, 2025
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myPHteam

"What side effects have others experienced with Remodulin/Treprostinil via IV, particularly fatigue during dose increases?"

Common side effects of prostanoid therapy include:
• Infusion site pain
• Jaw pain
• Extremity pain
• Headaches

These effects are related to the medication's pro- and anti-inflammatory properties Show Full Answer

"What side effects have others experienced with Remodulin/Treprostinil via IV, particularly fatigue during dose increases?"

Common side effects of prostanoid therapy include:
• Infusion site pain
• Jaw pain
• Extremity pain
• Headaches

These effects are related to the medication's pro- and anti-inflammatory properties. Each person's response can vary based on their individual immune system, pain tolerance, and lifestyle factors. Regarding fatigue specifically, many people with PH experience fatigue (about 60%). While adjusting to medication changes, temporary fatigue is common. Some helpful tips for managing fatigue include:

• Maintaining a balanced diet and staying hydrated
• Getting appropriate physical activity (as advised by your doctor)
• Keeping a fatigue diary to track patterns
• Practicing meditation
• Asking for help when needed

If fatigue persists or becomes concerning, always discuss this with your healthcare provider, as they may need to adjust your treatment plan.

August 24, 2025

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